Postdoctoral fellow · Penninger lab · University of British Columbia

Clément Quintard

I build microfluidic systems where stem cell-derived organoids are fed by their own blood vessels and visited by their own immune cells. The aim is human tissue models that are good enough to replace animals in drug development, and complex enough to be worth the trouble.

Outside the lab I am curious about most things. The blog is where that goes: science, nature, sport, and whatever I happen to be thinking of.

Research

Vascularized and immunized organoids-on-chip

I am a postdoctoral fellow in the lab of Josef Penninger at the University of British Columbia. My research sits at the interface of stem cell biology, organoid engineering and microfluidics, with a focus on developing functionally vascularized and immunized organoids-on-chip.

Before Vancouver, I did my PhD at CEA Grenoble, engineering vascularized organoids-on-chip with new microfluidic strategies. That work led to two first-author papers and a patent, and to a lasting interest in standardization, because organs-on-chip will only be adopted by industry if they become standardized and easy to use. I trained in physics at École Normale Supérieure Paris-Saclay, then in microfluidics at Institut Pierre-Gilles de Gennes, with research stays at Harvard and in an industrial collaboration with Sanofi.

AI tools have become part of my daily research, from analysis pipelines to experimental design. Bringing human microphysiological systems and AI together is, to me, one of the most promising directions for biology and drug discovery in the coming years.

  • Microfluidic platformsImproving throughput and scalability of organoid-on-chip systems.
  • Fully stem cell-derived modelsVessels, stroma and parenchyma from the same iPSC line, for physiological relevance.
  • Immune componentsImmune cell trafficking and interactions inside microphysiological systems.
  • New vascularization strategiesBeyond blood vessels, for heart, pancreas, lung, brain and cancer models.
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Publications

Selected papers and patents

Patents

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